引用本文:	吴佩,李婷,李敬,袁毅,张秀梅,韩丽君.海藻多糖空心胶囊药物溶出度研究[J].海洋科学,2010,34(2):19-22.

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海藻多糖空心胶囊药物溶出度研究
吴佩¹, 李婷², 李敬², 袁毅², 张秀梅¹, 韩丽君²
1.中国海洋大学;2.中国科学院海洋研究所

摘要:

海藻多糖空心胶囊是以海藻多糖与植物膳食纤维作为主要材料研制的一种植物空心胶囊。对海藻多糖植物空心胶囊(植物壳)、明胶空心胶囊的阿奇霉素、头孢氨苄和布洛芬3种药物模型的胶囊剂进行了药物溶出度和溶出速率的对比研究。结果显示海藻多糖空心胶囊在药物最终溶出量和加速稳定性试验上优于或同等于明胶空心胶囊, 因此海藻多糖空心胶囊具有代替动物明胶空心胶囊的潜在可能性。

关键词: 植物空心胶囊明胶空心胶囊药物溶出度

DOI：

分类号:

基金项目:国家863计划重点项目(2007AA091604); 中国科学院知识创新工程重要方向项目(KZCX2-YW-209)

The in vitro dissolution of algal polysaccharide hard shell capsules

WU Pei,LI Ting,LI Jing,YUAN Yi,ZHANG Xiu-mei,HAN Li-jun

Abstract:

Algal polysaccharide hard shell capsule is a kind of plant capsule mainly containing algal polysaccharide extracted from marine Rhodophyte and plant cellulose. The performances of in vitro dissolution of cefalexin, azithromycin, and ibuprofen of algal polysaccharide hard shell capsules have been investigated respectively and compared with that of gelatin capsules. This study confirmed that algal polysaccharide hard shell capsules were superior or equal to gelatin capsules in ultimate dissolution rates and accelerated stabilities. In this way, algal polysaccharide hard shell capsules can therefore be considered as a viable alternative to gelatin capsules.

Key words: plant capsules gelatin capsules in vitro dissolution