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海洋链霉菌L211 次生代谢产物分离和结构鉴定
郭书举^1,2, 苏华³, 李宪璀¹, 史大永¹, 朱校斌¹
1.中国科学院海洋研究所;2.中国科学院海洋研究所海洋科学与技术研究与发展中心;3.中国科学院青岛生物能源与过程研究所

摘要:

利用硅胶柱、凝胶柱及制备薄层色谱等色谱方法对海洋链霉菌Streptomyces sp. L211 发酵液的乙酸乙酯相浸膏进行了分离, 通过¹H-NMR、¹³C-NMR、EIMS 等方法鉴定了10 个化合物: Kalamycin (1),Medermycin (2), Menoxymycin-B (3), spatozoate (4), 邻氨基苯甲酸(5), 3-吲哚乙醇(6), 1-乙酰基咔啉(7),对羟基苯基乙醇(8), 吲哚-3-乙酸(9), 吲哚-3-甲酸(10)。

关键词: 海洋链霉菌次生代谢产物抗肿瘤活性

DOI：10.11759/hykx20130903003

分类号:

基金项目:江苏省自然科学基金项目(BK2011395); 国家海洋局公益性行业科研专项项目(201205025-5)

Isolation and identification of secondary metabolites produced by a marine-derived Streptomyces sp. L211

Abstract:

Ten compounds including Kalamycin (1), Medermycin (2), Menoxymycin-B (3), spatozoate (4), anthranilic acid(5), 3-indolylethanol(6), 1-acetyl-β-carbolin(7), p-hydroxyphenylethyl alcohol(8), indole-3-acetic acid(9), and indol-3-carboxylic acid(10) were isolated from the ethyl acetate extract of a marine-derived Streptomyces sp. L211 by using normal phase silica gel, Sephadex LH-20 chromatography and preparative thin layer chromatography. Their structures were identified by spectroscopic methods including ¹H-NMR, ¹³C-NMR and EIMS.

Key words: marine-derived actinomycete. secondary metabolites anti-tumor activity

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