| 摘要: |
| 从南海圆裂短足软珊瑚(Cladiella krempfi)中分离出12个甾体化合物，分别鉴定为：1,2-[1’,3’,4’]oxodithiin-pregna-20-en-3-one(1);19-nor-4-methylpregna-1,3,5(10), 20-tetraen-1-ol(2);pregna-1-en-3-one-20-ol(3); pregna-1,7-dien-20-ol-3-one(4);pregna-5,20-dien-3-O-α-fucopyranoside(5);pregna-20-en-3-O-α-fucopyranoiside(6);孕甾-1，20-二烯-3-酮（7）;孕甾-1，4，20-三烯-3-酮（8）;24-甲基-5α-胆甾-7,22-二烯-3β,5,6β-三醇（9）;26-甲基-24-亚甲基胆甾-5烯-3β-醇(10);胆甾-5-烯-3β-醇(11);β-谷甾醇(12)。化合物1～6系首次从Cladiella属软珊瑚中获得的孕甾类化合物。 对所获得化合物的生源途径进行了初步讨论。 |
| 关键词: 圆裂短足软珊瑚(Cladiella krempfi) 孕甾类化合物 生源途径 |
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| 基金项目:国家863计划项目(2001AA620403,2002AA217081)；国家自然科学基金项目（30530080，30171106，40176038） |
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| Steroids constituents from the soft coral Cladiella krempfi |
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HUANG Xin-ping,ZHU Xiao-bin,DENG Zhi-wei,LIN Wen-han
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| Abstract: |
| From the soft coral Cladiella krempfi collected from the inner reef of Hainan Island, the South China Sea, 12 compounds, named 1,2-[1’,3’,4’]oxodithiin-pregna-20-en-3-one(1);19-nor-4-methylpregna11,3,5(10), 20-tetraen-1-ol(2);pregna-1-en-3-one-20-ol(3);pregna-1,7-dien-20-ol-3-one(4);Pregna-5,20-dien-3-O-α-fucopyranoside(5);Pregna-20-en-3-O-α-fucopyranoiside(6);pregna-1,20-dien-3-one(7); 1,4,20-pregnatien-3-one(8); 24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol(9); 26-methyl-24-methylenecholest-5-en-3β-ol(10); Cholesta-5-en-3β-ol(11); β-sitosterol(12)were isolated.Their structures were identified by 1H and 13C NMR，2D NMR, MS spectral analysis and in comparison of the spectral data with those reported in literatures.Compounds 1～6 were isolated from the genus Cladiella for the first time. In addition, the plausible biogenetic paths for compounds were also discussed. |
| Key words: soft coral Cladiella krempfi pregnane biogenetic path |
