| 摘要: |
| 利用正相硅胶柱层析、反相硅胶柱层析、凝胶Sephadex LH-20柱层析、制备薄层层析(PTLC)及重结晶等分离手段,从鼠尾藻(Sargassum thunbergii)中分离得到8个化合物,通过MS、1D和2D NMR等波谱技术鉴定结构为:黑麦草内酯(1);Hexahydro-3a,6-dihydroxy-4,4,7a-tri methyl-2(3H)-benzofuranone(2);5-甲酯基-5-羟基-3-甲氧基-2-环戊烯-1-酮(3);顺 -1,6,9,12,15,18-二十一碳六烯酸(4);顺-5,8,11,14-二十碳四烯酸(5);顺-5,8,11,14,17-二十碳五烯酸甲酯 (6);植醇(7)和岩藻甾醇(8)。这些化合物均为首次从该海藻中分离获得。 |
| 关键词: 鼠尾藻(Sargassum thunbergii) 化学成分 结构鉴定 |
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| 基金项目:国家自然科学基金(30530080);山东省科技发展计划项目(2006GG2205023);海洋药物教育部重点实验室开放基金项目 |
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| Chemical constituents from Sargassum thunbergii |
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| Abstract: |
| From the brown alga Sargassum thunbergii, eight compounds were isolated by the normal phase silica gel, reverse phase silica gel, Sephadex LH-20 column chromatography separation, the preparative thin layer chromatography(PTLC) and re-crystallization. The structures of the purified compounds were elucidated by the analysis of spectroscopic method including MS, 1D and 2D NMR as loliolide (1), hexahydro-3a, 6-dihydroxy-4, 4, 7a-trimethyl-2(3H)-benzofuranone (2), 5-carbomethoxy-5-hydroxy-3-methoxy-2-cyclopenten-1-one (3), cis-1, 6, 9, 12, 15, 18-heneicosahexaene (4), cis-5, 8, 11, 14-eicosatetraenoic acid (5), methyl(cis-5, 8, 11, 14, 17)-eicosapentaenoate (6), phytol (7), and fucosterol (8). |
| Key words: Sargassum thunbergii chemical constituents structure elucidation |
