| 摘要: |
| 研究不同剂量壳寡糖延缓自发性II型糖尿病db/db小鼠糖代谢异常发生、发展过程的效果。每日灌胃壳寡糖(COS),定期观测小鼠体重、摄食量、空腹血糖、餐后血糖等,利用口服糖耐量实验的血糖曲线下面积(AUC),评价各组小鼠自发性II型糖尿病发展进程。各剂量COS均可有效维持db/db小鼠体重稳定、控制每日饮水量;可降低db/db小鼠空腹血糖、餐后血糖和AUC;延缓小鼠进入糖尿病前期和糖尿病阶段,其中各COS组糖尿病前期阶段可延长50%~100%。COS可减轻db/db小鼠的糖尿病早期症状,延缓其进入糖尿病前期和糖尿病阶段,延长病程前期发展过程,控制血糖水平从而在一定程度上阻滞II型糖尿病的发展进程。 |
| 关键词: 壳寡糖 II型糖尿病 自发性 db/db小鼠 糖尿病前期 |
| DOI：10.11759/hykx20210114001 |
| 分类号:S986.1;TS202 |
| 基金项目:江苏省高校“青蓝工程”中青年学术带头人培养项目;江苏省卫生职业技术教育研究课题(J201715) |
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| Chitooligosaccharides delay the course of type II diabetes mellitus in db/db mice |
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CHENG Qin-yuan, MA Ming, YAN Lin, WU Xiao-yu
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Wuxi Higher Health Vocational Technology School, Wuxi 214111, China
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| Abstract: |
| To study the effects of different dosages of Chitooligosaccharides on the occurrence and development of abnormal glucose metabolism in db/db mice with spontaneous type II diabetes mellitus. COS were given by gavage every day. The body weight, food intake, fasting blood glucose (FBG) and postprandial blood glucose (2hBG) of mice were observed regularly. Oral glucose tolerance test and its area under the blood glucose curve (AUC) was calculated to evaluate the development of spontaneous type II diabetes in db/db mice. COS could effectively maintain the weight stability of db/db mice, control the daily water intake; it could reduce FBG, 2hBG and the AUC of OGTT test in db/db mice; delay the time of mice entering the stage of pre-diabetes and diabetes mellitus, and prolong the period of mice in prediabetes from 50% to 100%, respectively. COS can improve the diabetic symptoms of db/db mice, delay the onset of prediabetes and diabetes mellitus, prolong the time of prediabetes, and block the course of type II diabetes mellitus. |
| Key words: Chitooligosaccharides type II diabetes mellitus spontaneous db/db mice prediabetes |
