引用本文:	韩华,李健,李吉涛,韩现芹,陈萍.喹诺酮类药物对牙鲆肝药物代谢酶活性的影响[J].海洋科学,2009,33(11):48-54.

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喹诺酮类药物对牙鲆肝药物代谢酶活性的影响
韩华^1,2, 李健², 李吉涛², 韩现芹^1,2, 陈萍²
1.上海海洋大学;2.中国水产科学院黄海水产研究所

摘要:

以牙鲆（Paralichthys olivaceus）为研究对象，通过观察水产用的3种喹诺酮类药物（FQ）恩诺沙星、诺氟沙星和氟甲喹分别对牙鲆肝组织中氨基比林N-脱甲基酶（AND）、红霉素N-脱甲基酶（ERND）和7-乙氧基异吩唑酮-脱乙基酶（EROD）活性的影响，探讨喹诺酮类药物对牙鲆肝药物代谢酶（细胞色素P-450）活性影响的差异。结果表明，与对照组比较，三组喹诺酮类药物对牙鲆肝S₉中AMND、ERND、EROD酶活性均具有抑制作用，其中恩诺沙星和诺氟沙星组中，3种酶的活性极显著下降（P＜0.01），而对于氟甲喹组而言，AMND、ERND酶活性显著下降（P＜0.05），EROD酶活性极显著下降（P＜0.01）。

关键词: 牙鲆（Paralichthys olivaceus）细胞色素P450 喹诺酮类药物

DOI：

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基金项目:科技部社会公益研究专项（2004DIB4JH165）；公益性农业行业科研专项（nyhyzx07-046）

Effects of quinolones on activity of hepatic drug metabolizing enzymes in Paralichthys olivaceus

HAN Hua,LI Jian,Li Ji-tao,HAN Xian-qin,Chen Ping

Abstract:

In order to observe the difference of effects of quinolones on the activity of drug-metabolism (cytochrome P-450), we studied the effects of quinolones（FQ）on the activities of APND,ERND and EROD in the liver of flounders (Paralichthys olivaceus). The results showed that the activities of APND, ERND and EROD in the S₉ mix were inhibited by the three kinds of quinolones on the different degrees, where enrofloxacin and norfloxacin treated groups had a very significant decrease on the activities of APND, ERND and EROD compared to the control group (P＜0.01), while flumequine treated group only decreased the activity of EROD very significantly (P＜0.01), and had a significant decrease on the activities of APND and ERND.

Key words: Paralichthys olivaceus Cytochrome P450 enzymes quinolones