引用本文:	王　淼,于海燕,欧阳健明.异枝麒麟菜硫酸多糖的降解及其对尿石矿物草酸钙的抑制作用[J].海洋科学,2008,32(8):34-37.

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异枝麒麟菜硫酸多糖的降解及其对尿石矿物草酸钙的抑制作用
王　淼¹, 于海燕¹, 欧阳健明¹
暨南大学生物矿化与结石病防治研究所

摘要:

采用过氧化氢法降解了相对分子质量约为141万±8.3万的海藻异枝麒麟菜(Eucheuma striatum Schmitz)硫酸多糖(ESPS),降解产物平均相对分子质量为4 819±440。降解后多糖的硫酸基(OSO^2-₃)质量分数稍有下降,由16.03%降至15.20%左右。同时, 用体外模拟方法研究了降解前后ESPS对草酸钙(CaOxa) 晶体生长的抑制作用,降解后的ESPS明显优于未降解多糖,其诱导生成的一水草酸钙(COM)晶体尺寸进一步减小,晶体数量减少,且棱角更为圆钝。表明低分子质量ESPS更能抑制CaOxa晶体的成核和生长。

关键词: 异枝麒麟菜(Eucheuma striatum Schmitz) 多糖降解草酸钙尿结石

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基金项目:广东省科技攻关项目(2006B36501001) ;国家自然科学基金项目(30672103 ,20471024) ;国家自然科学基金重点项目(20031010)

Degradation of sulfated polysaccharide from Eucheuma striatum and its inhibition on urinary mineral calcium oxalate

Abstract:

Algal Eucheuma striatum sulfated polysaccharide was degraded by hydrogen peroxide (H₂O₂) from average molecular weight of 1 410 000 ±83 000 to 4 819 ±440 or so. The mass fraction (w) of sulfate group (OSO^2-₃) decreased from 16.03% to 15.20%. The effects of ESPS before and after degradation on crystal growth of calcium oxalate (CaOxa) were investigated in vitro. The size and number of CaOxa crystals induced by degraded ESPS were much smaller than those of the undegraded polysaccharide, and the edges and angles of the former were much rounder and blunter. That is, the ESPS with a low molecular weight could more inhibit the nucleation and growth of CaOxa crystals.

Key words: Eucheuma striatum polysaccharide degradation calcium oxalate urinary stones