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藻类分子生物技术两年评─—与藻类活性物质研究有关的生物技术
严小军, 秦松, 曾呈奎
中国科学院海洋研究所 青岛 266071
摘要:
根据1992年6月-1994年6月国内外发表资料，评述海洋藻类活性物质研究的生物技术及最新成果。认为，海洋生物活性物质研究的重心正转向与海洋生物技术有关的研究。运用生物技术筛选、提取并生产藻类活性物质已经成为这一领域的主流。综合文献表明，藻类活性物质研究的生物技术正走向成熟，大量的活性物质被发现，光生物反应器将成为主要的下游生产技术，通过藻类基因工程生产药物已初现端倪。
关键词:  藻类  分子生物技术  生物活性物质  生物反应器
DOI：
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基金项目:国家科委、山东省科委攻关合同项目
TWO YEARS’ REVIEW ON ALGAL MOLECULAR BIOTECHNOLOGY-BIOTECHNOLOGY IN ALGAL BIOACTIVE COMPOUNDS RESEARCH
Yan Xiaojun, Qin Song, Zeng Chengkui (C. K. Tseng)
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071
Abstract:
The literature published mainly during the period from June 1992 to June 1994, showed that focus on marine bioactive compounds research was transferred to molecular biotechnology related research. Screening, extraction and production of marine algal bioactive compounds through molecular biotechnology have become the mainstream in this field especially for blue-green algae and dinoflagellates. Lots of bioactive natural products from marine microalgae have been discovered. The most distinctive compounds were macrolides such as tolytoxins, and cyclopeptides such as westiellamide. On the other hand, research on photobioreactor became more and more competitive as many new techniques have been patented by various biotechnology development companies. Pharmaceuticals production by algal genetic engineering is feasible.
Key words:  Algae, Molecular biotechnology, Bioactive compounds, Bioneactor
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